Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment
Published in Nucleic Acids Research, 2024
About the paper:
In this work, we investigated the archaeal RNA polymerase elongation complex using structural approaches.
Our findings reveal the mechanisms of Spt4/5 binding and its impact on transcriptional regulation.
It was exciting to visualize these processes at near-atomic resolution, which highlighted unexpected parallels between archaeal and eukaryotic transcription systems.
I mainly contributed by analyzing the mass spectrometry data and helping to interpret the related findings.
This study published in Nucleic Acids Research deepens our understanding of fundamental transcriptional control mechanisms in archaea.
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Recommended citation:
Tarau DM, Grünberger F, Pilsl M, et al. (2024). “Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment.” Nucleic Acids Research.
DOI:
10.1093/nar/gkae282