The archaeal Lsm protein from Pyrococcus furiosus binds co-transcriptionally to poly(U)-rich target RNAs
About the paper:
This study published in Biological Chemistry investigates the role of archaeal Sm-like proteins (PfuSmAP1) in posttranscriptional processes in the hyperthermophile Pyrococcus furiosus. Through mass spectrometry and transcriptome-wide binding site analysis, it identifies PfuSmAP1’s interaction partners, primarily components of the RNA homeostasis network. The study demonstrates that PfuSmAP1 selectively binds messenger RNAs and antisense RNAs, suggesting its involvement in regulatory functions at the posttranscriptional level without impacting transcriptional activity.
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Recommended citation:
Reichelt R., et al. (2023). "The archaeal Lsm protein from Pyrococcus furiosus binds co-transcriptionally to poly(U)-rich target RNAs." Biological Chemistry.
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