The archaeal Lsm protein from Pyrococcus furiosus binds co-transcriptionally to poly(U)-rich target RNAs
Published in Biological Chemistry, 2023
About the paper:
In this study, we explored the role of the archaeal Lsm protein in binding RNA targets during active transcription in Pyrococcus furiosus.
Our findings show that Lsm preferentially associates with poly(U)-rich RNA sequences co-transcriptionally, suggesting a regulatory role in RNA stability and processing.
I contributed by performing experimental validation of RNA-protein interactions and analyzing transcriptomic signatures linked to Lsm activity.
It was particularly exciting to discover parallels between archaeal RNA regulation and eukaryotic RNA-binding protein behavior.
This work broadens our understanding of RNA regulation mechanisms conserved across different domains of life.
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Recommended citation:
Reichelt R, Rothmeier T, Grünberger F, et al. (2023). “The archaeal Lsm protein from Pyrococcus furiosus binds co-transcriptionally to poly(U)-rich target RNAs.” Biological Chemistry, 404(11-12). DOI: 10.1515/hsz-2023-0215